ARID2: A new tumor suppressor gene in hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
ARID2: A new tumor suppressor gene in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent ...
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The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
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Objective: HOXD10, which regulates and maintains cell-differentiated phenotype, has involved in the tumorigenesis of many human cancers. However, the expression patterns and biological functions of HOXD10 in hepatocellular carcinoma (HCC) remain to be unclear. Therefore, we investigated the clinical and biological functions of HOXD10 in HCC in this work. Methods: HOXD10 expression was detected ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2011
ISSN: 1949-2553
DOI: 10.18632/oncotarget.355